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pentobarbital will lower the level or influence of linagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Use of other treatments is strongly advised when linagliptin will be to be administered having a CYP3A4 inducerContraindicated (1)pentobarbital will minimize the level or impact of lumacaftor/ivacaftor